- Active Substance: Isotretinoin
- Concentration: 20 mg/tab
- Pack Size: 50 tabs
- Manufacturer: Ultima Pharmaceuticals
- Brand Name: Accutane
SKU: P230
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Understanding Ultima-Accutane (Isotretinoin) for Severe Acne Management
Ultima-Accutane, from Ultima Pharmaceuticals, contains 20mg of Isotretinoin per tablet and is supplied in a pack of 50 tablets. Isotretinoin, also known as 13-cis-Retinoic acid and widely recognized under the brand name Accutane, is a powerful oral retinoid medication primarily indicated for the treatment of severe recalcitrant nodular acne that has proven resistant to other therapies, including systemic antibiotics.
Mechanism of Action
Isotretinoin is a retinoid, a compound structurally related to vitamin A. While its precise mechanism of action is not fully elucidated, it exerts its therapeutic effects through several key pathways. These include a significant suppression of sebaceous gland activity, leading to reduced sebum (oil) production; inhibition of comedogenesis (the formation of blackheads and whiteheads) by reducing abnormal keratinization within the hair follicle; a reduction in the size of the sebaceous glands; and anti-inflammatory effects.
Indications and Usage
Ultima-Accutane (Isotretinoin) is specifically indicated for severe nodular acne. Given its potential for significant adverse effects, its use is typically reserved for patients with severe acne that has not responded adequately to conventional treatment. The dosage of Isotretinoin is highly individualized, based on the patient's body weight and the severity of their condition, and is determined and monitored by a dermatologist.
Important Safety Information and Potential Side Effects
Isotretinoin is a teratogen, meaning it can cause severe birth defects if taken during pregnancy. Strict pregnancy prevention measures are mandatory for female patients of childbearing potential. Common side effects include cheilitis (inflammation of the lips), dry skin and mucous membranes (including the eyes and nose), increased susceptibility to sunburn, and musculoskeletal pain. More serious potential side effects can include elevated liver enzymes, hyperlipidemia (increased blood fats), and, rarely, psychiatric disorders such as depression and suicidal ideation. Regular medical monitoring, including blood tests, is essential during Isotretinoin therapy.
Dosage and Administration
Isotretinoin capsules are administered orally, usually once or twice daily with food to enhance absorption. The typical duration of treatment ranges from 16 to 24 weeks, aiming for a cumulative dose that has been shown to increase the likelihood of long-term remission. Patients must adhere strictly to the prescribed dosage and attend all scheduled follow-up appointments with their dermatologist.
FAQ
What is Ultima-Accutane (Isotretinoin) used for?
Ultima-Accutane (Isotretinoin) is a potent oral medication used to treat severe nodular acne that has not responded to other treatments.
How does Isotretinoin work to treat acne?
Isotretinoin works by reducing oil production in the skin, preventing pore blockage, reducing inflammation, and potentially affecting acne-causing bacteria.
What are some common side effects of Isotretinoin?
Common side effects include dry lips, dry skin, dry eyes, and nosebleeds.
What are the most serious risks associated with Isotretinoin?
The most serious risk is the potential for severe birth defects if taken during pregnancy. Other serious risks include potential effects on liver function and lipid levels.
How should Ultima-Accutane be taken?
It should be taken orally with food, as directed by a dermatologist, and patients should adhere to all medical advice and monitoring requirements.
Important Note: Ultima-Accutane (Isotretinoin) is a powerful prescription medication that must be used under the strict supervision of a qualified dermatologist. This information is for general knowledge and informational purposes only and does not constitute medical advice. Do not use this medication without a valid prescription and ongoing medical supervision.